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AREVIR-GenaFor-Meeting 2015

Monitoring von resistenten HIV bei frisch infizierten und chronisch infizierten HIV-Patienten in Deutschland

When: 08.05. - 09. 05. 2015 (9:00 am – 18:00 pm)

Where: Stadthotel am Römerturm, St. Apern-Str. 32, 50667 Köln

Registration is free like every year!

We have a restricted number of free rooms for the night from 08. - 09. May for young investigators. Additional rooms and further accommodations are available for special room rates!


Claudia.Mueller@med.uni-duesseldorf.de for registration and accommodation

Resistance testing is meanwhile „standard of care“. Different projects such as AREVIR, RESINA and RKI Serokonverter-Analyse and the new HIV-HEP-MASTER project contribute to better interpretation systems and analyze the risk of transmission of resistant HIV in Germany. On a European level the results of AREVIR and RESINA are continuously integrated into the EUResist project together with the Karolinska and ARCA data and other European partners (www.euresist.org ). Our aim is the prediction of the most likely best working drug combinations. For that reason, geno2pheno-THEO (www.genafor.org) was developed and integrated into the EUResist prediction tool which is also freely available via internet. Nevertheless we need to understand the contribution of each resistance associated mutation and we have to agree on strategies for resistance testing and interpretation. These are the aims of HIV-GRADE (www.hiv-grade.de). New antiretroviral drugs in new classes require equivalent diagnostics. Within HIV-GRADE and geno2pheno such interpretation tools have been developed and are being continuously updated. This includes the prediction of the coreceptor usage (tropism) prior to therapy with coreceptor blockers like maraviroc and resistance to the integrase inhibitors raltegravir, elvitegravir and dolutegravir. A workshop within the European project EucoHIV (www.eucohiv.org)for training and discussion on HIV-tropism is part of the meeting.

For HBV the technical expertise from the HIV-projects could be adapted, so that interpretation systems are already available. Geno2pheno and HIV-GRADE predict resistance, (sub-) genotype and escape mutants.

For HCV-therapy a new era has been entered with the availability of direct antiviral agents (DAAs). The protease inhibitors boceprevir and telaprevir are established on the market already and sofosbuvir has reached as the first polymerase inhibitor. Interpretation systems for the prediction of therapy success are needed and geno2pheno[HCV] as well as HIV-GRADE are meeting this challenge.

Since 2000 the meeting is an exchange platform for clinicians, bioinformaticians and virologists. Participants have the chance to discuss clinical cases with other experts – the fasta file of the relevant case from HIV, HBV, HCV and clinical information is needed, while the interpretation systems can be utilized online at the meeting. The suppliers of the commercial systems will also be present. Furthermore, protocols are available at the meeting and will be visible on the internet after the meeting under www.genafor.org.

The language of the meeting is English.