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AREVIR-GenaFor-Meeting 2010


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Donnerstag, 22. April 2010

Zeit Vorträge

09:00 - 09:15

Opening Comments
Jürgen Reifarth / Stiftung caesar

09:15 - 11:30

Chair: Maria Neumann-Fraune/ Stefan Reuter
Hepatitis B
HBV: Clinical aspects
HBV: Resistance testing, Determination of Genotype Escape-Variants
HBV: RESINA occult infection in HIV+
Speakers: Frank Wilhelm, Andreas Erhardt, Behrend Zacher, Bastian Beggel, Ke Zhang, Corinna Bremer


Prevalence and characteristics of Hepatitis B and C in HIV-infected patients from the RESINA cohort
Frank Clemens Wilhelm, Mark Oette, Rolf Kaiser, Bastian Beggel, Melanie Balduin, Finja Schweitzer, Jens Verheyen, Ortwin Adams, Dieter Häussinger


Analysis of HBV resistant mutants by phenotypic assay
Corinna M. Bremer


HBV Antiviral Drug Resistance
KeZhang, Christian Bach, Prof. Ulrike Protzer


geno2pheno[hbv] - A Web Service for HBV Drug Resistance Analysis
Bastian Beggel

11:30 - 11:45

Coffee break

11:45 - 13:30

Chair: Ulrich Spengler / Ulrike Protzer
Hepatitis C
HCV: Basics
HCV: new drugs
HCV: Resistance testing
HCV: Clinical aspects
Speakers: Ralf Bartenschlager, Wulf Böcher, Joke Snoeck, Michael Biermer, Christoph Welsch


BI 201335, a NS3/4A Serine Protease Inhibitor, and BI 207127, a NNI NS5b Polymerase Inhibitor for treatment of chronic HCV infection
Wulf Otto Böcher


Genotyping near full-length hepatitis C viruses
Snoeck Joke


What is to be expected from new antivirals against Hepatitis C? A clinician.s perspective.
Michael Biermer


The Future in Hepatitis C Treatment: Therapy Individualization and STAT-C
Christoph Welsch


Hepatitis C Virus: Basics
Ralf Bartenschlager

13:30 - 14:30


14:30 - 16:45

Chair: Lutz Gürtler / Martin Däumer
Is resistance disappearing?
Update of Tools for Resistance testing (HIV-Grade, geno2pheno)
Minorities and low viraemia
Speakers: Andrea De Luca, Hauke Walter, Alejandro Pironti, Martin Obermeier, Melanie Balduin, Martin Däumer, Dominic Heider, Oliver Kuhn


Heavy cross: how to compare 454 data from virus populations?
Martin Däumer


How less is enough?
Melanie Balduin


A Tool for Predicting the Success of First-Line Antiretroviral Therapies
Alejandro Pironti


HIV-GRADE Update 2010 and outlook
M. Obermeier


Free energy calculations on HIV-PR drug complexes
Oliver Kuhn


Rolf Kaiser

16:45 - 17:00

Coffee break

17:00 - 18:30

Chair: Susanna Trapp/ Thomas Harrer
“Other” regions of HIV
Host factors
HIV-2 tools and interpretation (update)
Speakers: Francoise Brun-Vezinet, Jens Verheyen, HIV-Grade, Thomas Harrer, Finja Schweitzer, Lutz Gürtler, Martin Stürmer, Evrim Anadol


HIV-2 Resistance to Antiretroviral Drugs


COMET: A Novel approach to HIV-1 subtype prediction
Daniel Struck


HIV-2 Resistance Interpretation and Update of Case Report
Martin Stürmer


HLA alleles in the context of RAMs in therapy naive patients
Finja Schweitzer


Etravirine Resistance Mutations and Immune selection
Sandra Müller


Transmission of Human Immunodeficiency Virus I Drug Resistance - A Case Report.
Evrim Anadol


HIV gag mutations: Every little helps
Jens Verheyen


Freitag, 23. April 2010

Zeit Vorträge

09:00 - 09:15

Patient view
Hans Thomas Sedlmayer

09:15 - 11:30

Chair: Francesca Incardona, Thomas Lengauer
EuResist(supported by Pfizer and Abbott) EuResist present and future:
The EuResist database and interpretation system
HIV resistance, treatment perspectives and data collection in Greece, Russia, Ethiopia, India, Tanzania, South Africa

Speakers: Maurizio Zazzi, Dimitrios Paraskevis, Marina Bobkova, Daniel Fekade, N. Kumarasamy, Tumaini Nagu, Ziad El-Khatib, Daniel Struck


EuResist Current status & perspectives
M. Zazzi


HIV treatment & ARV resistance issues in India
N. Kumarasamy


HIV-1 drug resistance in Greece
D. Paraskevis

11:30 - 11:45

Coffee break

11:45 - 13:30

Chair: Maurizio Zazzi, Eugen Schülter
Databases and projects
Data from the RESINA cohort
RKI-seroconverter study
Rega DB, Kompetenznetz, SnoB, Smartgene

Speakers: Mark Oette, Barbara Bartmeyer, Claudia Kücherer, Gertjan Beheydt, Klaus Jansen, Stefan Esser, Stefan Emler


Primary HIV Drug Resistance: The RESINA Study
Mark Oette


The CompNet resistance module: Current status
Klaus Jansen


Gertjan Beheydt


SnoB - INI-resistance in non-B Subtypes
Stefan Esser, Saleta Sierra-Aragón, Melanie Balduin, Andre Altmann, Hauke Walter, Rolf Kaiser


Patient- and Drug-specific Models for HIV Cell Entry
Thomas Lengauer

13:30 - 14:30


14:30 - 16:45

Chair: Carlo Perno, Herbert Pfister
„The Berlin patient“ (Bone Marrow transplant of delta 32CCR5)
Current techiques and protocols
Experiences from European countries
Speakers: Gero Hütter, Alexander Thielen, Saleta Sierra-Aragón, Martin Däumer, Valentina Svicher, Chris Verhofstede, Martin Obermeier, Thomas Klimkeit, Nico Dybowski, Malcom Mac Artney


HIV Eradication by Stem Cell Transplantation: Is It Feasible?
Gero Hütter


geno2pheno[454] - Coreceptor usage prediction with massively parallel sequencing
Alexander Thielen


Comparative HIV-1 tropism study using Trofile and geno2pheno[coreceptor] of 61 clinical samples
Saleta Sierra Aragon


Chris Verhofstede


The Berlin Maraviroc cohort
Martin Obermeier


Use of a genotypic assay for the prediction of HIV-1 co-receptor tropism and guiding the use of CCR5 antagonists in clinical practice
Malcolm Macartney, Jane Cameron, Angela Strang, Ana Garcia, Clare Booth, Neal Marshall, Margaret Johnson and Anna Maria Geretti


Genotypic Prediction of HIV-1 Coreceptor Usage and Application to Deep Sequencing
J. Nikolaj Dybowski


Coreceptor analysis - Current state in Germany and Europe
Rolf Kaiser

16:45 - 17:00

Coffee break

17:00 - 18:00

Chair: Patrick Braun, Alexander Thielen
Resistance/Coreceptor - Guidelines
European Guidelines
German Guidelines
Speakers: Annemarie Wensing, Hauke Walter, Hans-Jürgen Stellbrink


European Guidelines on HIV-1 tropism testing
Chris Verhofstede


Contribution of Hans-Jürgen Stellbrink ICH Hamburg Schriftführer Deutsche AIDS- Gesellschaft
Hans-Jürgen Stellbrink


EU resistance guidelines v.2009
Hauke Walter

18:00 - 18:30

Chair: Rolf Kaiser

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