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AREVIR-GenaFor-Meeting 2010

Program

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Donnerstag, 22. April 2010

Zeit Vorträge

09:00 - 09:15

Opening Comments
Jürgen Reifarth / Stiftung caesar

09:15 - 11:30

Chair: Maria Neumann-Fraune/ Stefan Reuter
Hepatitis B
HBV: Clinical aspects
HBV: Resistance testing, Determination of Genotype Escape-Variants
HBV: RESINA occult infection in HIV+
Speakers: Frank Wilhelm, Andreas Erhardt, Behrend Zacher, Bastian Beggel, Ke Zhang, Corinna Bremer

 

Prevalence and characteristics of Hepatitis B and C in HIV-infected patients from the RESINA cohort
Frank Clemens Wilhelm, Mark Oette, Rolf Kaiser, Bastian Beggel, Melanie Balduin, Finja Schweitzer, Jens Verheyen, Ortwin Adams, Dieter Häussinger

 

Analysis of HBV resistant mutants by phenotypic assay
Corinna M. Bremer

 

HBV Antiviral Drug Resistance
KeZhang, Christian Bach, Prof. Ulrike Protzer

 

geno2pheno[hbv] - A Web Service for HBV Drug Resistance Analysis
Bastian Beggel

11:30 - 11:45

Coffee break

11:45 - 13:30

Chair: Ulrich Spengler / Ulrike Protzer
Hepatitis C
HCV: Basics
HCV: new drugs
HCV: Resistance testing
HCV: Clinical aspects
Speakers: Ralf Bartenschlager, Wulf Böcher, Joke Snoeck, Michael Biermer, Christoph Welsch

 

BI 201335, a NS3/4A Serine Protease Inhibitor, and BI 207127, a NNI NS5b Polymerase Inhibitor for treatment of chronic HCV infection
Wulf Otto Böcher

 

Genotyping near full-length hepatitis C viruses
Snoeck Joke

 

What is to be expected from new antivirals against Hepatitis C? A clinician.s perspective.
Michael Biermer

 

The Future in Hepatitis C Treatment: Therapy Individualization and STAT-C
Christoph Welsch

 

Hepatitis C Virus: Basics
Ralf Bartenschlager

13:30 - 14:30

Lunch

14:30 - 16:45

Chair: Lutz Gürtler / Martin Däumer
HIV
Is resistance disappearing?
Update of Tools for Resistance testing (HIV-Grade, geno2pheno)
Resensitizing
Minorities and low viraemia
Speakers: Andrea De Luca, Hauke Walter, Alejandro Pironti, Martin Obermeier, Melanie Balduin, Martin Däumer, Dominic Heider, Oliver Kuhn

 

Heavy cross: how to compare 454 data from virus populations?
Martin Däumer

 

How less is enough?
Melanie Balduin

 

A Tool for Predicting the Success of First-Line Antiretroviral Therapies
Alejandro Pironti

 

HIV-GRADE Update 2010 and outlook
M. Obermeier

 

Free energy calculations on HIV-PR drug complexes
Oliver Kuhn

 

HIV-GRADE
Rolf Kaiser

16:45 - 17:00

Coffee break

17:00 - 18:30

Chair: Susanna Trapp/ Thomas Harrer
HIV
“Other” regions of HIV
Host factors
HIV-2 tools and interpretation (update)
Speakers: Francoise Brun-Vezinet, Jens Verheyen, HIV-Grade, Thomas Harrer, Finja Schweitzer, Lutz Gürtler, Martin Stürmer, Evrim Anadol

 

HIV-2 Resistance to Antiretroviral Drugs
Brun-Vezinet

 

COMET: A Novel approach to HIV-1 subtype prediction
Daniel Struck

 

HIV-2 Resistance Interpretation and Update of Case Report
Martin Stürmer

 

HLA alleles in the context of RAMs in therapy naive patients
Finja Schweitzer

 

Etravirine Resistance Mutations and Immune selection
Sandra Müller

 

Transmission of Human Immunodeficiency Virus I Drug Resistance - A Case Report.
Evrim Anadol

 

HIV gag mutations: Every little helps
Jens Verheyen

 

Freitag, 23. April 2010

Zeit Vorträge

09:00 - 09:15

Patient view
Hans Thomas Sedlmayer

09:15 - 11:30

Chair: Francesca Incardona, Thomas Lengauer
EuResist(supported by Pfizer and Abbott) EuResist present and future:
The EuResist database and interpretation system
HIV resistance, treatment perspectives and data collection in Greece, Russia, Ethiopia, India, Tanzania, South Africa

Speakers: Maurizio Zazzi, Dimitrios Paraskevis, Marina Bobkova, Daniel Fekade, N. Kumarasamy, Tumaini Nagu, Ziad El-Khatib, Daniel Struck

 

EuResist Current status & perspectives
M. Zazzi

 

HIV treatment & ARV resistance issues in India
N. Kumarasamy

 

HIV-1 drug resistance in Greece
D. Paraskevis

11:30 - 11:45

Coffee break

11:45 - 13:30

Chair: Maurizio Zazzi, Eugen Schülter
Databases and projects
Data from the RESINA cohort
RKI-CLINSERV
RKI-seroconverter study
Rega DB, Kompetenznetz, SnoB, Smartgene

Speakers: Mark Oette, Barbara Bartmeyer, Claudia Kücherer, Gertjan Beheydt, Klaus Jansen, Stefan Esser, Stefan Emler

 

Primary HIV Drug Resistance: The RESINA Study
Mark Oette

 

The CompNet resistance module: Current status
Klaus Jansen

 

RegaDB
Gertjan Beheydt

 

SnoB - INI-resistance in non-B Subtypes
Stefan Esser, Saleta Sierra-Aragón, Melanie Balduin, Andre Altmann, Hauke Walter, Rolf Kaiser

 

Patient- and Drug-specific Models for HIV Cell Entry
Thomas Lengauer

13:30 - 14:30

Lunch

14:30 - 16:45

Chair: Carlo Perno, Herbert Pfister
Coreceptor
„The Berlin patient“ (Bone Marrow transplant of delta 32CCR5)
Current techiques and protocols
Experiences from European countries
Speakers: Gero Hütter, Alexander Thielen, Saleta Sierra-Aragón, Martin Däumer, Valentina Svicher, Chris Verhofstede, Martin Obermeier, Thomas Klimkeit, Nico Dybowski, Malcom Mac Artney

 

HIV Eradication by Stem Cell Transplantation: Is It Feasible?
Gero Hütter

 

geno2pheno[454] - Coreceptor usage prediction with massively parallel sequencing
Alexander Thielen

 

Comparative HIV-1 tropism study using Trofile and geno2pheno[coreceptor] of 61 clinical samples
Saleta Sierra Aragon

 

TROPISM DETERMINATION IN BELGIUM
Chris Verhofstede

 

The Berlin Maraviroc cohort
Martin Obermeier

 

Use of a genotypic assay for the prediction of HIV-1 co-receptor tropism and guiding the use of CCR5 antagonists in clinical practice
Malcolm Macartney, Jane Cameron, Angela Strang, Ana Garcia, Clare Booth, Neal Marshall, Margaret Johnson and Anna Maria Geretti

 

Genotypic Prediction of HIV-1 Coreceptor Usage and Application to Deep Sequencing
J. Nikolaj Dybowski

 

Coreceptor analysis - Current state in Germany and Europe
Rolf Kaiser

16:45 - 17:00

Coffee break

17:00 - 18:00

Chair: Patrick Braun, Alexander Thielen
Resistance/Coreceptor - Guidelines
European Guidelines
German Guidelines
Speakers: Annemarie Wensing, Hauke Walter, Hans-Jürgen Stellbrink

 

European Guidelines on HIV-1 tropism testing
Chris Verhofstede

 

Contribution of Hans-Jürgen Stellbrink ICH Hamburg Schriftführer Deutsche AIDS- Gesellschaft
Hans-Jürgen Stellbrink

 

EU resistance guidelines v.2009
Hauke Walter

18:00 - 18:30

Chair: Rolf Kaiser
Summary

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